GOT1 antibody

• Background :

  Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H (2) S via the action of 3-mercaptopyruvate sulfurtransferase (3MST) . Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

• Synonyms :

  Aspartate aminotransferase, cytoplasmic (cAspAT) |Cysteine aminotransferase, cytoplasmic|Cysteine transaminase, cytoplasmic (cCAT) |Glutamate oxaloacetate transaminase 1|Transaminase A|GOT1

• Gene ID :

  2805

• UniProt :

  P17174

• Host :

  Mouse

• Reactivity :

  Human

• Immunogen :

  Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

• Target :

  GOT1

• Clonality :

  Monoclonal

• Isotype :

  IgG2a

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Neuroscience, Metabolism

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  43 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  2F1

• Tested Applications :

  ELISA, WB, IHC

• Immunogen Sequence :

  1-413aa