GOT1 antibody

• Background:

  Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase(3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

• Synonyms:

  Aspartate aminotransferase, cytoplasmic (cAspAT)|Cysteine aminotransferase, cytoplasmic|Cysteine transaminase, cytoplasmic (cCAT)|Glutamate oxaloacetate transaminase 1|Transaminase A|GOT1

• Gene ID:

  2805

• UniProt:

  P17174

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  glutamic-oxaloacetic transaminase 1, soluble(aspartate aminotransferase 1)

• Target:

  GOT1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP

• Field of Research:

  Neuroscience, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  43-46 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4