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GAD2 antibody

CAT: 0710-FNab03291Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03291Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Synonyms
Glutamate decarboxylase 2|65 kDa glutamic acid decarboxylase (GAD-65) |Glutamate decarboxylase 65 kDa isoform|GAD2|GAD65
Gene ID
2572
UniProt
Q05329
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Target
GAD2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Neuroscience, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC

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