GAB2 antibody

• Background :

  Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

• Synonyms :

  GRB2-associated-binding protein 2|GRB2-associated binder 2|Growth factor receptor bound protein 2-associated protein 2|pp100|GAB2|KIAA0571

• Gene ID :

  9846

• UniProt :

  Q9UQC2

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  GRB2-associated binding protein 2

• Target :

  GAB2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Immunology, Signal Transduction, Developmental biology

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  70-74 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC