FOXA2 antibody

• Background:

  Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity) . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

• Synonyms:

  Hepatocyte nuclear factor 3-beta (HNF-3-beta, HNF-3B) |Forkhead box protein A2|Transcription factor 3B (TCF-3B) |FOXA2|HNF3B|TCF3B

• Gene ID:

  3170

• UniProt:

  Q9Y261

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Forkhead box A2

• Target:

  FOXA2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IP, WB, IHC

• Field of Research:

  Epigenetics, Signal Transduction, Metabolism, Developmental biology, Neuroscience, Stem Cells

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  60 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IP, WB, IHC