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FOXA2 antibody

CAT: 0710-FNab03188Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab03188Size:100 µg
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Background
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity) . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Synonyms
Hepatocyte nuclear factor 3-beta (HNF-3-beta, HNF-3B) |Forkhead box protein A2|Transcription factor 3B (TCF-3B) |FOXA2|HNF3B|TCF3B
Gene ID
3170
UniProt
Q9Y261
Host
Rabbit
Reactivity
Human
Immunogen
Forkhead box A2
Target
FOXA2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB, IHC
Field of Research
Epigenetics, Signal Transduction, Metabolism, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB, IHC

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