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FANCL antibody

CAT: 0710-FNab03011Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03011Size:100 µg
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Background
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Synonyms
E3 ubiquitin-protein ligase FANCL|Fanconi anemia group L protein|Fanconi anemia-associated polypeptide of 43 kDa (FAAP43) |RING-type E3 ubiquitin transferase FANCL|FANCL|PHF9
Gene ID
55120
UniProt
Q9NW38
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fanconi anemia, complementation group L
Target
FANCL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
41-43 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q9NW38

E3 ubiquitin-protein ligase FANCL

FANCL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NW38
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FANCL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
Q6GU60
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

DNA damageDNA repairUbl conjugation pathway

Disease

Fanconi anemia

Ligand

Metal-bindingZinc

Molecular function

Transferase

Domain

Zinc-finger

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