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FANCL antibody

CAT: 0710-FNab03010Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03010Size:100 µg
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Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
Synonyms
E3 ubiquitin-protein ligase FANCL|Fanconi anemia group L protein|Fanconi anemia-associated polypeptide of 43 kDa (FAAP43) |RING-type E3 ubiquitin transferase FANCL|FANCL|PHF9
Gene ID
55120
UniProt
Q9NW38
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Fanconi anemia, complementation group L
Target
FANCL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200 - 1:2000; IHC: 1:20 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q9NW38

E3 ubiquitin-protein ligase FANCL

FANCL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NW38
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FANCL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
Q6GU60
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

DNA damageDNA repairUbl conjugation pathway

Disease

Fanconi anemia

Ligand

Metal-bindingZinc

Molecular function

Transferase

Domain

Zinc-finger

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