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FAM20C antibody

CAT: 0710-FNab02979Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02979Size:100 µg
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Background
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606) . Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039) . Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039) . Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606) . In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039) .
Synonyms
Extracellular serine/threonine protein kinase FAM20C|Dentin matrix protein 4 (DMP-4) |Golgi casein kinase|Golgi-enriched fraction casein kinase (GEF-CK) |FAM20C|DMP4
Gene ID
56975
UniProt
Q8IXL6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Family with sequence similarity 20, member C
Target
FAM20C
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
102-330 aa

UniProtKB · Q8IXL6

Extracellular serine/threonine protein kinase FAM20C

FA20C_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IXL6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FAM20C
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
Precursor
Secondary accessions
A4D2Q5, L8B5W8, Q5I0W9, Q7Z4I0, Q9NPT2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumManganeseMetal-bindingNucleotide-binding

Biological process

Biomineralization

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Cellular component

Endoplasmic reticulumGolgi apparatusMembraneSecreted

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Domain

Signal-anchorTransmembraneTransmembrane helix

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