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FADD antibody

CAT: 0710-FNab02941Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02941Size:100 µg
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Background
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Synonyms
FAS-associated death domain protein|FAS-associating death domain-containing protein|Growth-inhibiting gene 3 protein|Mediator of receptor induced toxicity|FADD|MORT1
Gene ID
8772
UniProt
Q13158
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fas (TNFRSF6) -associated via death domain
Target
FADD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IP
Field of Research
Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
26 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IP

UniProtKB · Q13158

FAS-associated death domain protein

FADD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13158
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FADD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q14866, Q6IBR4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

ApoptosisHost-virus interactionImmunityInnate immunity

Cellular component

Cytoplasm

Disease

Disease variant

PTM

GlycoproteinPhosphoprotein

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