EPHB4 antibody

• Background:

  Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

• Synonyms:

  Ephrin type-B receptor 4|Hepatoma transmembrane kinase|Tyrosine-protein kinase TYRO11|EPHB4|HTK|MYK1|TYRO11

• Gene ID:

  2050

• UniProt:

  P54760

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  EPH receptor B4

• Target:

  EPHB4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC, FC, WB

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  110 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC, FC, WB

• Immunogen Sequence:

  Extracellular,300-539AA