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EPHA8 antibody

CAT: 0710-FNab02806Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02806Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity) .
Synonyms
Ephrin type-A receptor 8|EPH- and ELK-related kinase|EPH-like kinase 3 (EK3, hEK3) |Tyrosine-protein kinase receptor EEK|EPHA8|EEK|HEK3|KIAA1459
Gene ID
2046
UniProt
P29322
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
EPH receptor A8
Target
EPHA8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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