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EBI3 antibody

CAT: 0710-FNab02615Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02615Size:100 µg
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Background
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro-and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17) . It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Synonyms
Interleukin-27 subunit beta (IL-27 subunit beta, IL-27B) |Epstein-Barr virus-induced gene 3 protein (EBV-induced gene 3 protein) |EBI3|IL27B
Gene ID
10148
UniProt
Q14213
Host
Rabbit
Reactivity
Human
Immunogen
Epstein-Barr virus induced 3
Target
EBI3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25-35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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