DPP4 antibody

CAT: 0710-FNab02520Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02520Size:100 µg
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Background
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR) -mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Synonyms
Dipeptidyl peptidase 4|ADABP|Adenosine deaminase complexing protein 2 (ADCP-2) |Dipeptidyl peptidase IV (DPP IV) |T-cell activation antigen CD26|TP103|Dipeptidyl peptidase 4 membrane form Alternative names: Dipeptidyl peptidase IV membrane form|Dipeptidyl peptidase 4 soluble form Alternative names: Dipeptidyl peptidase IV soluble form|DPP4|ADCP2|CD26
Gene ID
1803
UniProt
P27487
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Dipeptidyl-peptidase 4
Target
DPP4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Immunology, Cancer, Metabolism, Stem cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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