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DHX36 antibody

CAT: 0710-FNab02380Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02380Size:100 µg
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Background
Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
Synonyms
ATP-dependent DNA/RNA helicase DHX36|DEAD/H box polypeptide 36|DEAH-box protein 36|G4-resolvase-1 (G4R1) |MLE-like protein 1|RNA helicase associated with AU-rich element protein|DHX36|DDX36|KIAA1488|MLEL1|RHAU
Gene ID
170506
UniProt
Q9H2U1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
DEAH (Asp-Glu-Ala-His) box polypeptide 36
Target
DHX36
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

UniProtKB · Q9H2U1

ATP-dependent DNA/RNA helicase DHX36

DHX36_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H2U1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DHX36
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.12, 3.6.4.13
Processing
—
Secondary accessions
B2RB00, Q70JU3, Q8IYE5, Q9P240
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

ActivatorDevelopmental proteinDNA-bindingHelicaseHydrolaseRepressorRNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseDifferentiationImmunityInnate immunityTranscriptionTranscription regulationTranslation regulationTransport

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell projectionChromosomeCytoplasmMitochondrionNucleusTelomere

Domain

Coiled coilRepeat

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