DDB1 antibody

CAT: 0710-FNab02284Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02284Size:100 µg
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Background
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Synonyms
DNA damage-binding protein 1|DDB p127 subunit|DNA damage-binding protein a (DDBa) |Damage-specific DNA-binding protein 1|HBV X-associated protein 1 (XAP-1) |UV-damaged DNA-binding factor|UV-damaged DNA-binding protein 1 (UV-DDB 1) |XPE-binding factor (XPE-BF) |Xeroderma pigmentosum group E-complementing protein (XPCe) |DDB1|XAP1
Gene ID
1642
UniProt
Q16531
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Damage-specific DNA binding protein 1, 127kDa
Target
DDB1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
127 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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