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DCUN1D1 antibody

CAT: 0710-FNab02278Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02278Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211) . Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity) .
Synonyms
DCN1-like protein 1 (DCNL1) |DCUN1 domain-containing protein 1|Defective in cullin neddylation protein 1-like protein 1|Squamous cell carcinoma-related oncogene|DCUN1D1|DCN1|DCUN1L1|RP42|SCCRO
Gene ID
54165
UniProt
Q96GG9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
DCN1, defective in cullin neddylation 1, domain containing 1
Target
DCUN1D1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
28 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

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