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DBNL antibody

CAT: 0710-FNab02257Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02257Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity) . May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Synonyms
Drebrin-like protein|Cervical SH3P7|Cervical mucin-associated protein|Drebrin-F|HPK1-interacting protein of 55 kDa (HIP-55) |SH3 domain-containing protein 7|DBNL|CMAP|SH3P7
Gene ID
28988
UniProt
Q9UJU6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Drebrin-like
Target
DBNL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

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