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DACH2 antibody

CAT: 0710-FNab02231Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02231Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity) . Probably binds to DNA via its DACHbox-N domain.
Synonyms
Dachshund homolog 2 (Dach2) |DACH2
Gene ID
117154
UniProt
Q96NX9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Dachshund homolog 2 (Drosophila)
Target
DACH2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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