CXXC5 antibody

• Background:

  May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity) . Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788) . May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788) .

• Synonyms:

  CXXC-type zinc finger protein 5 (CF5) |Putative MAPK-activating protein PM08|Putative NF-kappa-B-activating protein 102|Retinoid-inducible nuclear factor (RINF) |CXXC5

• Gene ID:

  51523

• UniProt:

  Q7LFL8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  CXXC finger 5

• Target:

  CXXC5

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  35-40 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB