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CREB3L2 antibody

CAT: 0710-FNab01964Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01964Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor involved in unfolded protein response (UPR) . In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity) . In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827) . In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827) .
Synonyms
Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) |BBF2 human homolog on chromosome 7|Processed cyclic AMP-responsive element-binding protein 3-like protein 2|CREB3L2|BBF2H7
Gene ID
64764
UniProt
Q70SY1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CAMP responsive element binding protein 3-like 2
Target
CREB3L2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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