CPEB1 antibody

• Background :

  Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity) . Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity) . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity) . Induces the assembly of stress granules in the absence of stress.

• Synonyms :

  Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1, CPE-binding protein 1, h-CPEB, hCPEB-1) |CPEB1|CPEB

• Gene ID :

  64506

• UniProt :

  Q9BZB8

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Cytoplasmic polyadenylation element binding protein 1

• Target :

  CPEB1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Neuroscience, Metabolism, Developmental biology

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  54 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC