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COMT antibody

CAT: 0710-FNab01856Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01856Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Synonyms
Catechol O-methyltransferase|COMT
Gene ID
1312
UniProt
P21964
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Catechol-O-methyltransferase
Target
COMT
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
28 kDa, 32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB

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