CNDP2 antibody

• Background :

  Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245) . Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568) . Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880) . Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343) .

• Synonyms :

  Cytosolic non-specific dipeptidase|CNDP dipeptidase 2|Glutamate carboxypeptidase-like protein 1|Peptidase A|Threonyl dipeptidase|CNDP2|CN2|CPGL|HEL-S-13|PEPA

• Gene ID :

  55748

• UniProt :

  Q96KP4

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  CNDP dipeptidase 2 (metallopeptidase M20 family)

• Target :

  CNDP2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IF

• Field of Research :

  Cardiovascular, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  54 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IF