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CLSTN1 antibody

CAT: 0710-FNab01776Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01776Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity) .
Synonyms
Calsyntenin-1|Alcadein-alpha (Alc-alpha) |Alzheimer-related cadherin-like protein|Non-classical cadherin XB31alpha|Soluble Alc-alpha (SAlc-alpha) |CTF1-alpha Alternative names: C-terminal fragment 1-alpha|CLSTN1|CS1|KIAA0911
Gene ID
22883
UniProt
O94985
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Calsyntenin 1
Target
CLSTN1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
109 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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