Products for Research Use Only
RegisterLogin

CLP1 antibody

CAT: 0710-FNab01770Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0710-FNab01770Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810) . Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810) . Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC) . However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
Synonyms
Polyribonucleotide 5'-hydroxyl-kinase Clp1|Polyadenylation factor Clp1|Polynucleotide kinase Clp1|Pre-mRNA cleavage complex II protein Clp1|CLP1|HEAB
Gene ID
10978
UniProt
Q92989
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
CLP1, cleavage and polyadenylation factor I subunit, homolog
Target
CLP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

Related Products

CatalogName
EH7473Human CLP1 (Collectin placenta protein 1) ELISA Kit
P2786Recombinant human Isoform 2 of Polyribonucleotide 5'-hydroxyl-kinase Clp1
FNab01773CLPS antibody
FNab01771CLPB antibody
FNab01772CLPP antibody
FNab09999CLPX antibody
EH2231Human CLPP (Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial) ELISA Kit
P5892-01Recombinant Human CLPP
P1841-01Recombinant Human CLPP
P4469-01Recombinant Human CLPS

Alternative Products

CatalogName
GWB-MX099ICLP1 Antibody

Popular Products