CEP63 antibody

CAT: 0710-FNab01606Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01606Size:100 µg
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Background
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806) . Also recruits CDK1 to centrosomes (PubMed:21406398) . Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398) .
Synonyms
Centrosomal protein of 63 kDa (Cep63) |CEP63
Gene ID
80254
UniProt
Q96MT8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Centrosomal protein 63 kDaa
Target
CEP63
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57-75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP, IHC

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