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CEP152 antibody

CAT: 0710-FNab01597Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01597Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806) . Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615) . Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597) . Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity) . Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615) .
Synonyms
Centrosomal protein of 152 kDa (Cep152) |CEP152|KIAA0912
Gene ID
22995
UniProt
O94986
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Centrosomal protein 152kDa
Target
CEP152
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB
Field of Research
Cell Division, Proliferation, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB

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