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CENPF antibody

CAT: 0710-FNab01585Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01585Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Synonyms
Centromere protein F (CENP-F) |AH antigen|Kinetochore protein CENPF|Mitosin|CENPF
Gene ID
1063
UniProt
P49454
Host
Rabbit
Reactivity
Human
Immunogen
Centromere protein F, 350/400ka (mitosin)
Target
CENPF
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF
Field of Research
Epigenetics
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF

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