CDK6 antibody

CDK6 antibody

• Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Synonyms: Cyclin-dependent kinase 6|Cell division protein kinase 6|Serine/threonine-protein kinase PLSTIRE|CDK6|CDKN6
• CAS Number: 9007-83-4
• Gene ID: 1021
• UniProt: Q00534
• Host: Rabbit
• Reactivity: Human, Rat
• Immunogen: cyclin-dependent kinase 6
• Target: CDK6
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC
• Field of Research: Cell Division and Proliferation, Metabolism
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 37 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)