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CDK5RAP3 antibody

CAT: 0710-FNab01560Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01560Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517) . Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063) . Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857) . Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922) . May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784) . May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299) . May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629) . (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
Synonyms
CDK5 regulatory subunit-associated protein 3|CDK5 activator-binding protein C53|LXXLL/leucine-zipper-containing ARF-binding protein|Protein HSF-27|CDK5RAP3|IC53|LZAP
Gene ID
80279
UniProt
Q96JB5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CDK5 regulatory subunit associated protein 3
Target
CDK5RAP3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, FC
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, FC

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