CD79A antibody

• Background:

  Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

• Synonyms:

  B-cell antigen receptor complex-associated protein alpha chain|Ig-alpha|MB-1 membrane glycoprotein|Membrane-bound immunoglobulin-associated protein|Surface IgM-associated protein|CD79A|IGA|MB1

• Gene ID:

  973

• UniProt:

  P11912

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  CD79a molecule, immunoglobulin-associated alpha

• Target:

  CD79A

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  40 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  166-226aa