CD320 antibody

• Background:

  CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) . CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.

• Synonyms:

  CD320 antigen|8D6 antigen|FDC-signaling molecule 8D6 (FDC-SM-8D6) |Transcobalamin receptor (TCblR) |CD320|8D6A

• Gene ID:

  51293

• UniProt:

  Q9NPF0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  CD320 molecule

• Target:

  CD320

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Immunology, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:1000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-55 kDa, 60-70 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  80-282aa