CD3E antibody

• Background:

  CD3 is a complex of proteins that directly associates with the T cell receptor (TCR) . The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells. This anti-CD3 is a monoclonal antibody directed against the epsilon chain of human CD3 molecule.

• Synonyms:

  T-cell surface glycoprotein CD3 epsilon chain|T-cell surface antigen T3/Leu-4 epsilon chain|CD3E|T3E

• Gene ID:

  916

• UniProt:

  P07766

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  CD3e molecule, epsilon (CD3-TCR complex)

• Target:

  CD3E

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC, IF, FC

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:2000 - 1:20000; IHC: 1:1000 - 1:10000; IF: 1:50 - 500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  23 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  2E4

• Tested Applications:

  ELISA, WB, IHC, IF, FC

• Immunogen Sequence:

  1-207aa