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CD14 antibody

CAT: 0710-FNab01427Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01427Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655) . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135) . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211) . Binds electronegative LDL (LDL (-) ) and mediates the cytokine release induced by LDL (-) (PubMed:23880187) .
Synonyms
Monocyte differentiation antigen CD14|Myeloid cell-specific leucine-rich glycoprotein|Monocyte differentiation antigen CD14, urinary form|Monocyte differentiation antigen CD14, membrane-bound form|CD14
Gene ID
929
UniProt
P08571
Host
Mouse
Reactivity
Human, Mouse
Immunogen
CD14 molecule
Target
CD14
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Stem Cells, Immunology, Signal Transduction, Cancer
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
0G10
Tested Applications
ELISA, WB
Immunogen Sequence
1-375aa

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