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CBL antibody

CAT: 0710-FNab01317Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01317Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Synonyms
E3 ubiquitin-protein ligase CBL|Casitas B-lineage lymphoma proto-oncogene|Proto-oncogene c-Cbl|RING finger protein 55|RING-type E3 ubiquitin transferase CBL|Signal transduction protein CBL|CBL|CBL2|RNF55
Gene ID
867
UniProt
P22681
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Target
CBL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
117 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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