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CAV1 antibody

CAT: 0710-FNab01314Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01314Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Synonyms
Caveolin-1|CAV1|CAV
Gene ID
857
UniProt
Q03135
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Caveolin 1, caveolae protein, 22kDa
Target
CAV1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
22 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
0H8
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
11-178aa

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