Cleaved CASP9 antibody

• Background:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.This antibody can recognize the pre- and cleaved- caspase 9.

• Synonyms:

  Caspase-9 (CASP-9) |Apoptotic protease Mch-6|Apoptotic protease-activating factor 3 (APAF-3) |ICE-like apoptotic protease 6 (ICE-LAP6) |Caspase-9 subunit p35|Caspase-9 subunit p10|CASP9|MCH6

• Gene ID:

  842

• UniProt:

  P55211

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Caspase 9, apoptosis-related cysteine peptidase

• Target:

  Cleaved CASP9

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200 - 1:200; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  17 kDa/36 kDa/46 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF

• Immunogen Sequence:

  1-159aa