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CAPNS1 antibody

CAT: 0710-FNab01250Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01250Size:100 µg
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Background
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Synonyms
Calpain small subunit 1 (CSS1) |Calcium-activated neutral proteinase small subunit (CANP small subunit) |Calcium-dependent protease small subunit (CDPS) |Calcium-dependent protease small subunit 1|Calpain regulatory subunit|CAPNS1|CAPN4|CAPNS
Gene ID
826
UniProt
P04632
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Calpain, small subunit 1
Target
CAPNS1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
28 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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