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CAMKK2 antibody

CAT: 0710-FNab01238Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01238Size:100 µg
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Background
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca (2+) signals (By similarity) . Seems to be involved in hippocampal activation of CREB1 (By similarity) . May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Synonyms
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2, CaM-kinase kinase 2, CaMKK 2) |Calcium/calmodulin-dependent protein kinase kinase beta (CaM-KK beta, CaM-kinase kinase beta, CaMKK beta) |CAMKK2|CAMKKB|KIAA0787
Gene ID
10645
UniProt
Q96RR4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Calcium/calmodulin-dependent protein kinase kinase 2, beta
Target
CAMKK2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Neuroscience, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55-60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC
Immunogen Sequence
1-353

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