CALCOCO2 antibody

CAT: 0710-FNab01196Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01196Size:100 µg
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Background
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324) . Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791) . Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791) . May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994) .
Synonyms
Calcium-binding and coiled-coil domain-containing protein 2|Antigen nuclear dot 52 kDa protein|Nuclear domain 10 protein NDP52 (Nuclear domain 10 protein 52) |Nuclear dot protein 52|CALCOCO2|NDP52
Gene ID
10241
UniProt
Q13137
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Calcium binding and coiled-coil domain 2
Target
CALCOCO2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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