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CAD antibody

CAT: 0710-FNab01183Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01183Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
Multifunctional protein CAD|Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase|CAD
Gene ID
790
UniProt
P27708
Host
Rabbit
Reactivity
Human
Immunogen
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Target
CAD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
243 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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