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C8A antibody

CAT: 0710-FNab01139Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01139Size:100 µg
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Background
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
Synonyms
Complement component C8 alpha chain|Complement component 8 subunit alpha|C8A
Gene ID
731
UniProt
P07357
Host
Rabbit
Reactivity
Human
Immunogen
Complement component 8, alpha polypeptide
Target
C8A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
271-496aa

UniProtKB · P07357

Complement component C8 alpha chain

CO8A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07357
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
C8A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2RUI4, A2RUI5, Q13668, Q9H130
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Biological process

Complement alternate pathwayComplement pathwayCytolysisImmunityInnate immunity

Disease

Disease variant

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane beta strand

Cellular component

MembraneMembrane attack complexSecretedTarget cell membraneTarget membrane

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