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C4BPB antibody

CAT: 0710-FNab01114Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01114Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Synonyms
C4b-binding protein beta chain|C4BPB
Gene ID
725
UniProt
P20851
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Complement component 4 binding protein, beta
Target
C4BPB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40-45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF
Immunogen Sequence
18-252aa

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