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CTCFL antibody

CAT: 0710-FNab00932Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00932Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CTCFL, also named BORIS (for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR) . Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
Synonyms
Transcriptional repressor CTCFL|Brother of the regulator of imprinted sites|CCCTC-binding factor|CTCF paralog|CTCF-like protein|Cancer/testis antigen 27 (CT27) |Zinc finger protein CTCF-T|CTCFL|BORIS
Gene ID
140690
UniProt
Q8NI51
Host
Mouse
Reactivity
Human, Mouse
Immunogen
CCCTC-binding factor (zinc finger protein) -like
Target
CTCFL
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IF
Field of Research
Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
2B10
Tested Applications
ELISA, WB, IF
Immunogen Sequence
361-663aa