BMI1 antibody

• Background:

  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

• Synonyms:

  Polycomb complex protein BMI-1|Polycomb group RING finger protein 4|RING finger protein 51|BMI1|PCGF4|RNF51

• Gene ID:

  648

• UniProt:

  P35226

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  BMI1 polycomb ring finger oncogene

• Target:

  BMI1

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC, IF, IP

• Field of Research:

  Epigenetics, Metabolism, Cancer, Developmental biology, Stem Cells, Cell Division and Proliferation

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  37 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  8D5

• Tested Applications:

  ELISA, WB, IHC, IF, IP

• Immunogen Sequence:

  1-326aa