ARL2 antibody

• Background :

  Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) . GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca (2+) -dependent release of acetylcholine. Required for normal progress through the cell cycle.

• Synonyms :

  ADP-ribosylation factor-like protein 2|ARL2

• Gene ID :

  402

• UniProt :

  P36404

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  ADP-ribosylation factor-like 2

• Target :

  ARL2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  21-25 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC