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AQP4 antibody

CAT: 0710-FNab00521Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00521Size:100 µg
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Background
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Synonyms
Aquaporin-4 (AQP-4) |Mercurial-insensitive water channel (MIWC) |WCH4|AQP4
Gene ID
361
UniProt
P55087
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Aquaporin 4
Target
AQP4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
253-323aa, Cytoplasmic

UniProtKB · P55087

Aquaporin-4

AQP4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55087
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AQP4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AQP-4
EC number
—
Processing
—
Secondary accessions
P78564
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembrane

Disease

Disease variant

PTM

GlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

RepeatTransmembraneTransmembrane helix

Biological process

Transport

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