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APOBEC3G antibody

CAT: 0710-FNab00495Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00495Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) . May inhibit the mobility of LTR and non-LTR retrotransposons.
Synonyms
DNA dC->dU-editing enzyme APOBEC-3G|APOBEC-related cytidine deaminase (APOBEC-related protein, ARCD) |APOBEC-related protein 9 (ARP-9) |CEM-15 (CEM15) |Deoxycytidine deaminase (A3G) |APOBEC3G
Gene ID
60489
UniProt
Q9HC16
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Target
APOBEC3G
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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