APLF antibody

• Background:

  Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly (ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.

• Synonyms:

  Aprataxin and PNK-like factor|Apurinic-apyrimidinic endonuclease APLF|PNK and APTX-like FHA domain-containing protein|XRCC1-interacting protein 1|APLF|C2orf13|PALF|XIP1

• Gene ID:

  200558

• UniProt:

  Q8IW19

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Aprataxin and PNKP like factor

• Target:

  APLF

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  60 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB