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APEX1 antibody

CAT: 0710-FNab00479Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00479Size:100 µg
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Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Synonyms
DNA- (apurinic or apyrimidinic site) endonuclease|APEX nuclease (APEN) |Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1, APE-1) |REF-1|Redox factor-1|DNA- (apurinic or apyrimidinic site) endonuclease, mitochondrial|APEX1|APE|APE1|APEX|APX|HAP1|REF1
Gene ID
328
UniProt
P27695
Host
Rabbit
Reactivity
Human
Immunogen
APEX nuclease (multifunctional DNA repair enzyme) 1
Target
APEX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IF
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IF: 1:50 - 1:100; IP: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
39 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IF
Immunogen Sequence
1-318aa

UniProtKB · P27695

DNA repair nuclease/redox regulator APEX1

APEX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P27695
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APEX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.11.2, 3.1.21.-
Processing
—
Secondary accessions
Q969L5, Q99775
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCleavage on pair of basic residuesDisulfide bondPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-bindingEndonucleaseExonucleaseHydrolaseNucleaseRepressorRNA-binding

Cellular component

CytoplasmEndoplasmic reticulumMitochondrionNucleus

Biological process

DNA damageDNA recombinationDNA repairTranscriptionTranscription regulation

Ligand

MagnesiumMetal-binding

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